Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29740
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17775/20116 (88%)
Visitors : 10231867      Online Users : 471
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29740


    Title: Multicarotenoids at Physiological Levels Inhibit Metastasis in Human Hepatocarcinoma SK-Hep-1 Cells
    Authors: Chen, Huei-Yan
    Yang, Chih-Min
    Chen, Jen-Yin
    Yueh, Te-Cheng
    Hu, Miao-Lin
    Contributors: 老人服務事業管理系
    Keywords: Beta-carotene
    Matrix metalloproteinases
    Hepatocellular-carcinoma
    Cancer prevention
    Alpha-carotene
    Hepatoma-cells
    Lycopene
    Invasion
    Lutein
    Expression
    Date: 2015-05
    Issue Date: 2016-04-19 19:06:29 (UTC+8)
    Publisher: Routledge Journals
    Abstract: Several studies have demonstrated that single carotenoid, including lycopene, beta-carotene, and alpha-carotene, exhibits antimetastatic effects; however, little is known whether multicarotenoids have similar effects. Herein, we investigated the antimetastatic effect of multicarotenoids at physiological serum levels in Taiwanese (MCT at 1.4 mu M) and American (MCA at 1.8 mu M) populations using human hepatocarcinoma SK-Hep-1 cells in comparison with single carotenoid, such as lycopene (0.3 or 0.6 mu M, respectively), alpha-carotene (0.1 mu M), beta-carotene (0.4 mu M), lutein (0.4 or 0.5 mu M, respectively), and beta-cryptoxanthin (0.2 mu M). Results reveal that MCA treatment exhibited an additive inhibition on invasion, migration and adhesion at 24 and 48h of incubation, whereas MCT treatment possessed additive inhibition at 48h of incubation. The antimetastatic action of MCT and MCA involved additive reduction on activities of matrix metalloproteinase (MMP)-2, -9, and protein expression of Rho and Rac 1 but additive promotion on protein expression of tissue inhibitor of MMP (TIMP)-1 and -2. All of these effects were stronger in MCA than in MCT at 24 and 48h of incubation. These results demonstrate that multi-carotenoids effectively inhibit metastasis of human hepatocarcinoma SK-Hep-1 cells. More in vivo studies are needed to confirm these findings.
    Relation: Nutrition And Cancer-An International Journal, v.67 n.4, pp.676-686
    Appears in Collections:[Dept. of Senior Citizen Management] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML588View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback