Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29740
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18074/20272 (89%)
造访人次 : 4077970      在线人数 : 1175
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/29740


    標題: Multicarotenoids at Physiological Levels Inhibit Metastasis in Human Hepatocarcinoma SK-Hep-1 Cells
    作者: Chen, Huei-Yan
    Yang, Chih-Min
    Chen, Jen-Yin
    Yueh, Te-Cheng
    Hu, Miao-Lin
    貢獻者: 老人服務事業管理系
    關鍵字: Beta-carotene
    Matrix metalloproteinases
    Hepatocellular-carcinoma
    Cancer prevention
    Alpha-carotene
    Hepatoma-cells
    Lycopene
    Invasion
    Lutein
    Expression
    日期: 2015-05
    上傳時間: 2016-04-19 19:06:29 (UTC+8)
    出版者: Routledge Journals
    摘要: Several studies have demonstrated that single carotenoid, including lycopene, beta-carotene, and alpha-carotene, exhibits antimetastatic effects; however, little is known whether multicarotenoids have similar effects. Herein, we investigated the antimetastatic effect of multicarotenoids at physiological serum levels in Taiwanese (MCT at 1.4 mu M) and American (MCA at 1.8 mu M) populations using human hepatocarcinoma SK-Hep-1 cells in comparison with single carotenoid, such as lycopene (0.3 or 0.6 mu M, respectively), alpha-carotene (0.1 mu M), beta-carotene (0.4 mu M), lutein (0.4 or 0.5 mu M, respectively), and beta-cryptoxanthin (0.2 mu M). Results reveal that MCA treatment exhibited an additive inhibition on invasion, migration and adhesion at 24 and 48h of incubation, whereas MCT treatment possessed additive inhibition at 48h of incubation. The antimetastatic action of MCT and MCA involved additive reduction on activities of matrix metalloproteinase (MMP)-2, -9, and protein expression of Rho and Rac 1 but additive promotion on protein expression of tissue inhibitor of MMP (TIMP)-1 and -2. All of these effects were stronger in MCA than in MCT at 24 and 48h of incubation. These results demonstrate that multi-carotenoids effectively inhibit metastasis of human hepatocarcinoma SK-Hep-1 cells. More in vivo studies are needed to confirm these findings.
    關聯: Nutrition And Cancer-An International Journal, v.67 n.4, pp.676-686
    显示于类别:[高齡福祉養生管理系] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML1757检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈