Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29735
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    標題: VAV3 Oncogene Expression in Colorectal Cancer: Clinical Aspects and Functional Characterization
    作者: Uen, Yih-Huei
    Fang, Chia-Lang
    Hseu, You-Cheng
    Shen, Pei-Chun
    Yang, Hsin-Ling
    Wen, Kuo-Shan
    Hung, Shih-Ting
    Wang, Lu-Hai
    Lin, Kai-Yuan
    貢獻者: 保健營養系
    關鍵字: nucleotide exchange factor
    prostate-cancer
    cell-transformation
    breast-cancer
    receptor
    activation
    invasion
    progression
    survival
    motility
    日期: 2015-03
    上傳時間: 2016-04-19 19:06:19 (UTC+8)
    出版者: Nature Publishing Group
    摘要: Although colorectal cancer (CRC) is one of the most common malignancies worldwide, the current therapeutic approaches for advanced CRC are ineffective. In this study, we investigated the involvement of the VAV3 oncogene in tumor progression and in the prognosis of human CRC. The two patient cohorts in this study comprised 354 CRC cases from 1998 to 2005 with documented pathologic and clinical factors and clinical outcomes. VAV3 protein levels were significantly correlated with the depth of invasion (P = 0.0259), the nodal status (P < 0.0001), distant metastasis (P = 0.0354), the stage (P < 0.0001), and poor disease-free survival (P = 0.003). Multivariate Cox regression analysis showed that VAV3 overexpression is an independent prognostic marker for CRC (P = 0.041). In vitro experiments indicated that VAV3 knockdown inhibited CRC cell growth, spread, and xenograft proliferation. Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of cell cycle control-and metastasis-related molecules by activating the PI3K-AKT signaling pathway in both CRC cells and xenografts. This study suggests that VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC.
    關聯: Scientific Reports, v.5, Article ID 9360
    顯示於類別:[保健營養系(所) ] 期刊論文

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