VAV3 Oncogene Expression in Colorectal Cancer: Clinical Aspects and Functional Characterization

doi:10.1038/srep09360

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/29735

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29735

Title:	VAV3 Oncogene Expression in Colorectal Cancer: Clinical Aspects and Functional Characterization
Authors:	Uen, Yih-Huei Fang, Chia-Lang Hseu, You-Cheng Shen, Pei-Chun Yang, Hsin-Ling Wen, Kuo-Shan Hung, Shih-Ting Wang, Lu-Hai Lin, Kai-Yuan
Contributors:	保健營養系
Keywords:	nucleotide exchange factor prostate-cancer cell-transformation breast-cancer receptor activation invasion progression survival motility
Date:	2015-03
Issue Date:	2016-04-19 19:06:19 (UTC+8)
Publisher:	Nature Publishing Group
Abstract:	Although colorectal cancer (CRC) is one of the most common malignancies worldwide, the current therapeutic approaches for advanced CRC are ineffective. In this study, we investigated the involvement of the VAV3 oncogene in tumor progression and in the prognosis of human CRC. The two patient cohorts in this study comprised 354 CRC cases from 1998 to 2005 with documented pathologic and clinical factors and clinical outcomes. VAV3 protein levels were significantly correlated with the depth of invasion (P = 0.0259), the nodal status (P < 0.0001), distant metastasis (P = 0.0354), the stage (P < 0.0001), and poor disease-free survival (P = 0.003). Multivariate Cox regression analysis showed that VAV3 overexpression is an independent prognostic marker for CRC (P = 0.041). In vitro experiments indicated that VAV3 knockdown inhibited CRC cell growth, spread, and xenograft proliferation. Mechanistic studies further revealed that VAV3 overexpression could dysregulate the expression of cell cycle control-and metastasis-related molecules by activating the PI3K-AKT signaling pathway in both CRC cells and xenografts. This study suggests that VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC.
Relation:	Scientific Reports, v.5, Article ID 9360
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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