Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/29713
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    標題: Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion
    作者: Ko, Yen-Ling
    Sun, Chi-Shu
    Chung, Kun-Ming
    Lin, Yu-Min
    Feng, I-Che
    Sheu, Ming-Jen
    Koay, Lok-Beng
    Lin, Ching-Yih
    Ho, Chung-Han
    Kuo, Hsing-Tao
    貢獻者: 醫務管理系
    老人服務事業管理系
    關鍵字: e-antigen seroconversion
    virus-infection
    abdominal lymphadenopathy
    hepatocellular-carcinoma
    antibody seroconversion
    acute exacerbations
    chinese patients
    natural-history
    liver-disease
    core antigen
    日期: 2015-02
    上傳時間: 2016-04-19 19:05:34 (UTC+8)
    出版者: Public Library Science
    摘要: It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic lymph node sizes of 87 patients with acute flares of CHB were documented, with a median follow up of 43 months. Patients were separated into 3 groups, HBeAg-positive with HBe seroconversion (group 1), HBeAg-positive without HBe seroconversion (group 2), and HBeAg-negative (group 3). Group 1 has the highest incidence of enlarged lymph nodes (92.3%) compared with group 2 (75.8%) and group 3 (46.8%) (p = 0.003). And if nodal width at acute flare was >8mm and interval change of nodal width was >3mm, the incidence of HBeAg seroconversion will be 75% (p<0.001).
    Conclusion
    Larger perihepatic lymph nodes are seen in CHB acute flare patients with positive HBeAg and the magnitude of nodal width change may predict HBeAg seroconversion at recovery.
    關聯: Plos One, v.10 n.2, Article ID e0117590
    顯示於類別:[高齡福祉養生管理系] 期刊論文
    [醫務管理系(所)] 期刊論文

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