Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion

doi:10.1371/journal.pone.0117590

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Title:	Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion
Authors:	Ko, Yen-Ling Sun, Chi-Shu Chung, Kun-Ming Lin, Yu-Min Feng, I-Che Sheu, Ming-Jen Koay, Lok-Beng Lin, Ching-Yih Ho, Chung-Han Kuo, Hsing-Tao
Contributors:	醫務管理系老人服務事業管理系
Keywords:	e-antigen seroconversion virus-infection abdominal lymphadenopathy hepatocellular-carcinoma antibody seroconversion acute exacerbations chinese patients natural-history liver-disease core antigen
Date:	2015-02
Issue Date:	2016-04-19 19:05:34 (UTC+8)
Publisher:	Public Library Science
Abstract:	It has been observed that enlargement of perihepatic lymph nodes may be seen in patients with chronic hepatitis B, particularly during acute flares of CHB. We hypothesized that there may be a correlation between the nodal change patterns in CHB patients with acute flare and HBeAg status. Perihepatic lymph node sizes of 87 patients with acute flares of CHB were documented, with a median follow up of 43 months. Patients were separated into 3 groups, HBeAg-positive with HBe seroconversion (group 1), HBeAg-positive without HBe seroconversion (group 2), and HBeAg-negative (group 3). Group 1 has the highest incidence of enlarged lymph nodes (92.3%) compared with group 2 (75.8%) and group 3 (46.8%) (p = 0.003). And if nodal width at acute flare was >8mm and interval change of nodal width was >3mm, the incidence of HBeAg seroconversion will be 75% (p<0.001). Conclusion Larger perihepatic lymph nodes are seen in CHB acute flare patients with positive HBeAg and the magnitude of nodal width change may predict HBeAg seroconversion at recovery.
Relation:	Plos One, v.10 n.2, Article ID e0117590
Appears in Collections:	[Dept. of Senior Service and Health Management] Periodical Articles [Dept. of Hospital and Health (including master's program)] Periodical Articles

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