Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria

doi:10.3390/ijms161226184

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標題:	Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria
作者:	Chiou, Shu-Yuan Ha, Choi-Lan Wu, Pei-Shan Yeh, Chiu-Ling Su, Ying-Shan Li, Man-Po Wu, Ming-Jiuan
貢獻者:	保健營養系生物科技系
關鍵字:	Camellia tenuifloria monophenolase diphenolase iNOS macrophages
日期:	2015-12
上傳時間:	2016-04-19 19:04:51 (UTC+8)
出版者:	Mdpi Ag
摘要:	Camellia tenuifloria is an indigenous Camellia species used for the production of camellia oil in Taiwan. This study investigated for the first time the potential antioxidant, anti-tyrosinase and anti-inflammatory activities of oil production byproducts, specifically those of the fruit shell, seed shell, and seed pomace from C. tenuifloria. It was found that the crude ethanol extract of the seed shell had the strongest DPPH scavenging and mushroom tyrosinase inhibitory activities, followed by the fruit shell, while seed pomace was the weakest. The IC50 values of crude extracts and fractions on monophenolase were smaller than diphenolase. The phenolic-rich methanol fraction of seed shell (SM) reduced nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. It also repressed the expression of IL-1, and secretion of prostaglandin E-2 (PGE(2)) and IL-6 in response to LPS. SM strongly stimulated heme oxygenase 1 (HO-1) expression and addition of zinc protoporphyrin (ZnPP), a HO-1 competitive inhibitor, reversed the inhibition of NO production, indicating the involvement of HO-1 in its anti-inflammatory activity. The effects observed in this study provide evidence for the reuse of residues from C. tenuifloria in the food additive, medicine and cosmetic industries.
關聯:	International Journal of Molecular Sciences, v.16 n.12, pp.29522-29541
显示于类别:	[生物科技系(所)] 期刊論文 [保健營養系(所) ] 期刊論文

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