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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29622


    標題: Higher Risk of Developing Sudden Sensorineural Hearing Loss in Patients With Chronic Otitis Media
    作者: Yen, Yung-Chang
    Lin, Charlene
    Weng, Shih-Feng
    Lin, Yung-Song
    貢獻者: 醫務管理系
    關鍵字: Population-basedc ohort
    Disease
    Atherosclerosis
    Pathology
    日期: 2015-05
    上傳時間: 2016-04-19 19:02:21 (UTC+8)
    出版者: Amer Medical Assoc
    摘要: IMPORTANCE Several sources have suggested an association between chronic sensory hearing impairment and chronic otitis media (COM). However, to our knowledge, no studies have evaluated the risk of sudden sensorineural hearing loss (SSNHL) in patients with COM (COM-positive).OBJECTIVE To examine the risk of developing SSNHL in COM-positive patients.DESIGN, SETTING, AND PARTICIPANTS This was a retrospective cohort study; we compared 10 248 patients with newly diagnosed COM from January 1, 2001, through December 31, 2008, with 30 744 age-and sex-matched controls using data from Taiwan's National Health Insurance Research Database.METHODS We followed each patient and evaluated the incidence of SSNHL.MAIN OUTCOMES AND MEASURES The incidence of SSNHL at the end of 2011.RESULTS The incidence of SSNHL was 3 times higher in the COM-positive cohort than in the COM-negative cohort (14.47 vs 4.83 per 10 000 person-years). Cox proportional hazard regressions showed that the adjusted hazard ratio (AHR) was 3.02 (95% CI, 2.30-3.98). A stratified analysis showed that the highest risk of developing SSNHL was in the first follow-up year (incidence rate ratio [IRR], 3.87; 95% CI, 1.93-7.79). Thereafter, the risk declined during years 1 to 5 and then peaked (IRR, 3.01; 95% CI, 1.89-4.79). Patients who needed surgery had a higher incidence of SSNHL (AHR, 2.69; 95% CI, 1.62-4.48) compared with patients who needed only medication and observation.CONCLUSIONS AND RELEVANCE Chronic otitis media was significantly associated with a higher risk of developing SSNHL.
    關聯: Jama Otolaryngology-Head & Neck Surgery, v.141 n.5, pp.429-435
    Appears in Collections:[醫務管理系(所)] 期刊論文

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