Higher Risk of Developing Sudden Sensorineural Hearing Loss in Patients With Chronic Otitis Media

doi:10.1001/jamaoto.2015.102

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 醫務管理系(所) > 期刊論文 > Item 310902800/29622

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標題:	Higher Risk of Developing Sudden Sensorineural Hearing Loss in Patients With Chronic Otitis Media
作者:	Yen, Yung-Chang Lin, Charlene Weng, Shih-Feng Lin, Yung-Song
貢獻者:	醫務管理系
關鍵字:	Population-basedc ohort Disease Atherosclerosis Pathology
日期:	2015-05
上傳時間:	2016-04-19 19:02:21 (UTC+8)
出版者:	Amer Medical Assoc
摘要:	IMPORTANCE Several sources have suggested an association between chronic sensory hearing impairment and chronic otitis media (COM). However, to our knowledge, no studies have evaluated the risk of sudden sensorineural hearing loss (SSNHL) in patients with COM (COM-positive).OBJECTIVE To examine the risk of developing SSNHL in COM-positive patients.DESIGN, SETTING, AND PARTICIPANTS This was a retrospective cohort study; we compared 10 248 patients with newly diagnosed COM from January 1, 2001, through December 31, 2008, with 30 744 age-and sex-matched controls using data from Taiwan's National Health Insurance Research Database.METHODS We followed each patient and evaluated the incidence of SSNHL.MAIN OUTCOMES AND MEASURES The incidence of SSNHL at the end of 2011.RESULTS The incidence of SSNHL was 3 times higher in the COM-positive cohort than in the COM-negative cohort (14.47 vs 4.83 per 10 000 person-years). Cox proportional hazard regressions showed that the adjusted hazard ratio (AHR) was 3.02 (95% CI, 2.30-3.98). A stratified analysis showed that the highest risk of developing SSNHL was in the first follow-up year (incidence rate ratio [IRR], 3.87; 95% CI, 1.93-7.79). Thereafter, the risk declined during years 1 to 5 and then peaked (IRR, 3.01; 95% CI, 1.89-4.79). Patients who needed surgery had a higher incidence of SSNHL (AHR, 2.69; 95% CI, 1.62-4.48) compared with patients who needed only medication and observation.CONCLUSIONS AND RELEVANCE Chronic otitis media was significantly associated with a higher risk of developing SSNHL.
關聯:	Jama Otolaryngology-Head & Neck Surgery, v.141 n.5, pp.429-435
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