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| 標題: | Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats |
| 作者: | Chen, Yu-Wen
Tzeng, Jann-Inn
Lin, Min-Fei
Hung, Ching-Hsia
Wang, Jhi-Joung |
| 貢獻者: | 食品科技系 |
| 關鍵字: | long-term potentiation
low-frequency tens
painful diabetic-neuropathy
chronic constriction injury
postoperative pain
mechanicalallodynia
glial activation
nociceptive transmission
central sensitization
noxious-stimulation |
| 日期: | 2015-01 |
| 上傳時間: | 2016-04-19 19:01:13 (UTC+8) |
| 出版者: | Amer Physical Therapy Assoc |
| 摘要: | Background. Transcutaneous electrical nerve stimulation (TENS) is often used for management of chronic pain.Objective. The purpose of this study was to investigate whether TENS altered postincisional allodynia, substance P, and proinflammatory cytokines in a rat model of skin-muscle incision and retraction (SMIR).Design. This was an experimental study.Methods. High-frequency (100-Hz) TENS therapy began on postoperative day 3 and was administered for 20 minutes daily to SMIR-operated rats by self-adhesive electrodes delivered to skin innervated via the ipsilateral dorsal rami of lumbar spinal nerves L1-L6 for the next 27 days. The expressions of substance P, tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1 beta) in the spinal cord and mechanical sensitivity to von Frey stimuli (4g and 10g) were evaluated.Results. The SMIR-operated rats displayed a marked hypersensitivity to von Frey stimuli on postoperative day 3. In. contrast to the SMIR-operated rats, SMIR-operated rats after TENS administration showed a quick recovery of mechanical hypersensitivity. On postoperative days 3, 16, and 30, SMIR-operated rats exhibited an upregulation of substance P and cytokines (TNF-alpha, IL-6, and IL-1 beta) in the spinal cord, whereas SMIR-operated rats after TENS therapy inhibited that upregulation. By contrast, the placebo TENS following SMIR surgery did not alter mechanical hypersensitivity and the levels of spinal substance P, TNF-alpha, IL-6, and IL-1 beta.Limitations. The experimental data are limited to animal models and cannot be generalized to postoperative pain in humans.Conclusions. The results revealed that TENS attenuates prolonged postoperative allodynia following SMIR surgery. Increased levels of spinal substance P and proinflammatory cytokines, activated after SMIR surgery, are important in the processing of persistent postsurgical allodynia. The protective effect of TENS may be related to the suppression of spinal substance P and proinflammatory cytokines in SMIR-operated rats. |
| 關聯: | Physical Therapy, v.95 n.1, pp.76-85 |
| 顯示於類別: | [ 食品科技系 ] 期刊論文
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