Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats

doi:10.2522/ptj.20130306

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/29588

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/29588

Title:	Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Allodynia and Suppresses Spinal Substance P and Proinflammatory Cytokine Release in Rats
Authors:	Chen, Yu-Wen Tzeng, Jann-Inn Lin, Min-Fei Hung, Ching-Hsia Wang, Jhi-Joung
Contributors:	食品科技系
Keywords:	long-term potentiation low-frequency tens painful diabetic-neuropathy chronic constriction injury postoperative pain mechanicalallodynia glial activation nociceptive transmission central sensitization noxious-stimulation
Date:	2015-01
Issue Date:	2016-04-19 19:01:13 (UTC+8)
Publisher:	Amer Physical Therapy Assoc
Abstract:	Background. Transcutaneous electrical nerve stimulation (TENS) is often used for management of chronic pain.Objective. The purpose of this study was to investigate whether TENS altered postincisional allodynia, substance P, and proinflammatory cytokines in a rat model of skin-muscle incision and retraction (SMIR).Design. This was an experimental study.Methods. High-frequency (100-Hz) TENS therapy began on postoperative day 3 and was administered for 20 minutes daily to SMIR-operated rats by self-adhesive electrodes delivered to skin innervated via the ipsilateral dorsal rami of lumbar spinal nerves L1-L6 for the next 27 days. The expressions of substance P, tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1 beta) in the spinal cord and mechanical sensitivity to von Frey stimuli (4g and 10g) were evaluated.Results. The SMIR-operated rats displayed a marked hypersensitivity to von Frey stimuli on postoperative day 3. In. contrast to the SMIR-operated rats, SMIR-operated rats after TENS administration showed a quick recovery of mechanical hypersensitivity. On postoperative days 3, 16, and 30, SMIR-operated rats exhibited an upregulation of substance P and cytokines (TNF-alpha, IL-6, and IL-1 beta) in the spinal cord, whereas SMIR-operated rats after TENS therapy inhibited that upregulation. By contrast, the placebo TENS following SMIR surgery did not alter mechanical hypersensitivity and the levels of spinal substance P, TNF-alpha, IL-6, and IL-1 beta.Limitations. The experimental data are limited to animal models and cannot be generalized to postoperative pain in humans.Conclusions. The results revealed that TENS attenuates prolonged postoperative allodynia following SMIR surgery. Increased levels of spinal substance P and proinflammatory cytokines, activated after SMIR surgery, are important in the processing of persistent postsurgical allodynia. The protective effect of TENS may be related to the suppression of spinal substance P and proinflammatory cytokines in SMIR-operated rats.
Relation:	Physical Therapy, v.95 n.1, pp.76-85
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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