In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1

doi:10.1155/2015/568079

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標題:	In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1
作者:	Tang, Hung-Jen Ku, Yee-Huang Lee, Mei-Feng Chuang, Yin-Ching Yu, Wen-Liang
貢獻者:	保健營養系
關鍵字:	Spectrum beta-lactamases Enterobacteriaceae Combination Infections Therapy TAIWAN
日期:	2015
上傳時間:	2016-04-19 19:00:53 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	We investigated the synergism of colistin and imipenem against a multidrug-resistant K. pneumoniae isolate which was recovered from a severe hip infection. PCR and DNA sequencing were used to characterize the outermembrane porin genes and the resistance genes mediating the common beta-lactamases and carbapenemases. Synergism was evaluated by time-kill studies. The bla(SHV-31), bla(CMY-2), and bla(DHA-1) were detected. Outer membrane porin genes analysis revealed loss of ompK36 and frame-shift mutation of ompK35. The common carbapenemase genes were not found. Time-kill studies demonstrated that a combination of 1x MIC of colistin (2 mg/L) and 1x MIC of imipenem (8 mg/L) was synergistic and bactericidal but with inoculum effect. Bactericidal activity without inoculum effect was observed by concentration of 2x MIC of colistin alone or plus 2x MIC of imipenem. In conclusion, colistin plus imipenem could be an alternative option to treat carbapenem-resistant K. pneumoniae infections.
關聯:	Biomed Research International,V.2015 ,Article ID 568079
顯示於類別:	[保健營養系(所) ] 期刊論文

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