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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/29578


    標題: In Vitro Activity of Imipenem and Colistin against a Carbapenem-Resistant Klebsiella pneumoniae Isolate Coproducing SHV-31, CMY-2, and DHA-1
    作者: Tang, Hung-Jen
    Ku, Yee-Huang
    Lee, Mei-Feng
    Chuang, Yin-Ching
    Yu, Wen-Liang
    貢獻者: 保健營養系
    關鍵字: Spectrum beta-lactamases
    Enterobacteriaceae
    Combination
    Infections
    Therapy
    TAIWAN
    日期: 2015
    上傳時間: 2016-04-19 19:00:53 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: We investigated the synergism of colistin and imipenem against a multidrug-resistant K. pneumoniae isolate which was recovered from a severe hip infection. PCR and DNA sequencing were used to characterize the outermembrane porin genes and the resistance genes mediating the common beta-lactamases and carbapenemases. Synergism was evaluated by time-kill studies. The bla(SHV-31), bla(CMY-2), and bla(DHA-1) were detected. Outer membrane porin genes analysis revealed loss of ompK36 and frame-shift mutation of ompK35. The common carbapenemase genes were not found. Time-kill studies demonstrated that a combination of 1x MIC of colistin (2 mg/L) and 1x MIC of imipenem (8 mg/L) was synergistic and bactericidal but with inoculum effect. Bactericidal activity without inoculum effect was observed by concentration of 2x MIC of colistin alone or plus 2x MIC of imipenem. In conclusion, colistin plus imipenem could be an alternative option to treat carbapenem-resistant K. pneumoniae infections.
    關聯: Biomed Research International,V.2015 ,Article ID 568079
    Appears in Collections:[保健營養系(所) ] 期刊論文

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