Determination of Oleanolic and Ursolic Acids in Hedyotis diffusa Using Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography

doi:10.1155/2015/450547

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 環境工程與科學系(所) > 期刊論文 > Item 310902800/29576

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標題:	Determination of Oleanolic and Ursolic Acids in Hedyotis diffusa Using Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography
作者:	Wei, Ming-Chi Yang, Yu-Chiao Hong, Show-Jen
貢獻者:	環境工程與科學系
關鍵字:	Barbata D.don Rp-HPLC separation Iridoid glucosides CO2 extraction Herbal tea Optimization Lycopene Solubility Globulus Seeds
日期:	2015
上傳時間:	2016-04-19 19:00:49 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	Oleanolic acid (OA) and ursolic acid (UA) were extracted from Hedyotis diffusa using a hyphenated procedure of ultrasound-assisted and supercritical carbon dioxide (HSC-CO2) extraction at different temperatures, pressures, cosolvent percentages, and SC-CO2 flow rates. The results indicated that these parameters significantly affected the extraction yield. The maximal yields of OA (0.917 mg/g of dry plant) and UA (3.540 mg/g of dry plant) were obtained at a dynamic extraction time of 110 min, a static extraction time of 15 min, 28.2 MPa, and 56 degrees C with a 12.5% (v/v) cosolvent (ethanol/water = 82/18, v/v) and SC-CO2 flowing at 2.3 mL/min (STP). The extracted yields were then analyzed by high performance liquid chromatography (HPLC) to quantify the OA and UA. The present findings revealed that H. diffusa is a potential source of OA and UA. In addition, using the hyphenated procedure for extraction is a promising and alternative process for recovering OA and UA from H. diffusa at high concentrations.
關聯:	Evidence-Based Complementary And Alternative Medicine, Article ID 450547
顯示於類別:	[環境工程與科學系(所)] 期刊論文

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