開發Rhodobacter sphaeroide改良菌株生產之類茄紅素改善大鼠前列腺肥大功效

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標題:	開發Rhodobacter sphaeroide改良菌株生產之類茄紅素改善大鼠前列腺肥大功效 Development of Lycogen from Transformant Rhodobacter sphaeroide for Efficacy on Improving Prostatic Hyperplasia in Rats
作者:	楊彩秀
貢獻者:	嘉南藥理大學保健營養系(含碩士班)
日期:	2014
上傳時間:	2015-11-06 16:10:01 (UTC+8)
摘要:	本計畫之合作廠商透過 Rhodobacter sphaeroide 改良菌株可順利大量生產與茄紅素結構類似之物質lycogen，已進一步取代茄紅素缺點(取得不易與高成本)。研究中發現lycogen 具有顯著的美白、防皺抗老化與抗發炎的功效；更因產學合作案而開發成一系列美白產品，並以商業原料販售，廣泛應用於化妝保養品。近期我們已進行lycogen 的毒性試驗，確認lycogen 可應用於食品原料開發上。在先前廠商亦發現lycogen 明顯可透過抗氧化、抗發炎特性進而達到抑制前列腺癌細胞生長的效果。目前前列腺肥大的原因不明，老化及荷爾蒙的不平衡為原因。研究顯示前列腺肥大與前列腺特定抗原息息相關。在前列腺相關疾病中，前列腺特定抗原扮演關鍵重要的角色。因此，lycogen 是否具有抑制前列腺肥大是值得探討的。結合合作廠商的評估及我們的研究技術後，我們將採用大鼠注射睪固酮誘發前列腺肥大動物模式。除此之外，我們與合作之廠商欲進一步了解lycogen 是否藉由增加體內抗氧化系統，進而抑制睪固酮、二氫睪固酮與前列腺特定抗原含量，同時確認lycogen 對肝臟無毒性。本計劃可提供正確科學研究數據給合作之廠商，以利lycogen 未來做為一保健食品之開發。透過此合作計畫的執行，可以提升合作廠商的產業競爭力與研發能力。參與本計劃的研究團隊成員同時可獲得專案研究的實務經驗。 The cooperative business finds that it can be successfully produced mass lycopene and can be obtained smoothly and decreased the prime cost with the method of transformant Rhodobacter sphaeroide production, and through purification to find out the pure compound, lycogen, which is similar to lycopene in structure. According to our findings of the previous cooperative projects, lycogen had significantly effects on whitening, anti-wrinkling, anti-aging and anti-inflammation. Consequently, we also established a series of commercial goods with our cooperative business. Lycogen has been well application in cosmetic and skin care field. Recently, we have finished the toxicity assessment of lycogen, and speculated that lycogen may be applied in food development. In previous findings from our cooperative business, lycogen can significantly inhibit cell proliferation in prostate cancer cell lines through efficacy of its anti-oxidation and anti-inflammation. So far, the main reason of prostatic hyperplasia is still unclear. Studies indicate that prostatic hyperplasia has greatly associated with prostate specific antigen (PSA). PSA plays an extremely vital role in the prostate-related diseases. Hence, it will be worthy to investigating whether lycogen has effectiveness to attenuate prostatic hyperplasia. With evaluation by the cooperative business and our research technical support, we will use the animal model of prostatic hyperplasia evoked by testosterone injection to study. Besides that, we and our cooperative business will further observe whether that lycogen can inhibit the levels of testosterone, dihydrotestosterone (DHT), and PSA by increasing the ability of anti-oxidative defense system in vivo. Meanwhile, we will also examine that lycogen is harmless for live to confirm the security. Though executing this project, it will be beneficial to develop the lycogen in food application, and to promote the researching and competitive abilities for our cooperative business. Meanwhile, the members of team, who participate in this project, will learn the practical experiences and investigative techniques.
關聯:	計畫編號：NSC102-2410-H041-006 計畫年度：103；起迄日期：2013-08-01~2014-07-44
顯示於類別:	[保健營養系(所) ] 科技部計畫

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