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| 標題: | Virulence Diversity among Bacteremic Aeromonas Isolates: Ex Vivo, Animal, and Clinical Evidences |
| 作者: | Chen, Po-Lin
Wu, Chi-Jung
Tsai, Pei-Jane
Tang, Hung-Jen
Chuang, Yin-Ching
Lee, Nan-Yao
Lee, Ching-Chi
Li, Chia-Wen
Li, Ming-Chi
Chen, Chi-Chung
Tsai, Hung-Wen
Ou, Chun-Chun
Chen, Chang-Shi
Ko, Wen-Chien |
| 貢獻者: | 保健營養系 |
| 關鍵字: | HEMOLYTIC TOXIN GENES
SUCKLING MOUSE MODEL
SALMONELLA BACTEREMIA
NECROTIZING FASCIITIS
SOFT-TISSUE
HYDROPHILA
INFECTIONS
AQUARIORUM
STRAINS
SOBRIA |
| 日期: | 2014-11 |
| 上傳時間: | 2015-05-06 21:26:56 (UTC+8) |
| 出版者: | Public Library Science |
| 摘要: | Background: The objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. Methodology/Principal Findings: Nine of four species of Aeromonas blood isolates, including A. dhakensis, A. hydrophila, A. veronii and A. caviae were randomly selected for analysis. The species was identified by the DNA sequence matching of rpoD. Clinically, the patients with A. dhakensis bacteremia had a higher sepsis-related mortality rate than those with other species (37.5% vs. 0%, P = 0.028). Virulence of different Aeromonas species were tested in C. elegans, mouse fibroblast C2C12 cell line and BALB/c mice models. C. elegans fed with A. dhakensis and A. caviae had the lowest and highest survival rates compared with other species, respectively (all P values <0.0001). A. dhakensis isolates also exhibited more cytotoxicity in C2C12 cell line (all P values <0.0001). Fourteen-day survival rate of mice intramuscularly inoculated with A. dhakensis was lower than that of other species (all P values <0.0001). Hemolytic activity and several virulence factor genes were rarely detected in the A. caviae isolates. Conclusions/Significance: Clinical data, ex vivo experiments, and animal studies suggest there is virulence variation among clinically important Aeromonas species. |
| 關聯: | Plos One, v.9 n.11, e111213 |
| 顯示於類別: | [保健營養系(所) ] 期刊論文
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