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    Title: Virulence Diversity among Bacteremic Aeromonas Isolates: Ex Vivo, Animal, and Clinical Evidences
    Authors: Chen, Po-Lin
    Wu, Chi-Jung
    Tsai, Pei-Jane
    Tang, Hung-Jen
    Chuang, Yin-Ching
    Lee, Nan-Yao
    Lee, Ching-Chi
    Li, Chia-Wen
    Li, Ming-Chi
    Chen, Chi-Chung
    Tsai, Hung-Wen
    Ou, Chun-Chun
    Chen, Chang-Shi
    Ko, Wen-Chien
    Contributors: 保健營養系
    Date: 2014-11
    Issue Date: 2015-05-06 21:26:56 (UTC+8)
    Publisher: Public Library Science
    Abstract: Background: The objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. Methodology/Principal Findings: Nine of four species of Aeromonas blood isolates, including A. dhakensis, A. hydrophila, A. veronii and A. caviae were randomly selected for analysis. The species was identified by the DNA sequence matching of rpoD. Clinically, the patients with A. dhakensis bacteremia had a higher sepsis-related mortality rate than those with other species (37.5% vs. 0%, P = 0.028). Virulence of different Aeromonas species were tested in C. elegans, mouse fibroblast C2C12 cell line and BALB/c mice models. C. elegans fed with A. dhakensis and A. caviae had the lowest and highest survival rates compared with other species, respectively (all P values <0.0001). A. dhakensis isolates also exhibited more cytotoxicity in C2C12 cell line (all P values <0.0001). Fourteen-day survival rate of mice intramuscularly inoculated with A. dhakensis was lower than that of other species (all P values <0.0001). Hemolytic activity and several virulence factor genes were rarely detected in the A. caviae isolates. Conclusions/Significance: Clinical data, ex vivo experiments, and animal studies suggest there is virulence variation among clinically important Aeromonas species.
    Relation: Plos One, v.9 n.11, e111213
    Appears in Collections:[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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