Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28717
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17775/20116 (88%)
造访人次 : 10200486      在线人数 : 453
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/28717


    標題: The protective effects of glutamine in a rat model of ventilator-induced lung injury
    作者: Chen, Chin-Ming
    Cheng, Kuo-Chen
    Li, Chien-Feng
    Zhang, Haibo
    貢獻者: 休閒保健管理系
    關鍵字: Acute respiratory distress syndrome (ARDS)
    mechanical ventilation (MV)
    glutamine (GLN)
    cytokines
    日期: 2014-12
    上傳時間: 2015-05-06 21:26:16 (UTC+8)
    出版者: Pioneer Bioscience Publ Co
    摘要: Background: The mortality rate of patients with acute respiratory distress syndrome (ARDS) is still high despite the use of protective ventilatory strategies. We sought to examine the pharmacological effects of glutamine (GLN) in a two-hit model of endotoxin-induced inflammation followed by ventilator-induced lung injury (VILI). We hypothesized that the administration of GLN ameliorates the VILI. Methods: Sprague-Dawley rats were anesthetized and given lipopolysaccharide (LPS) intratracheally as a first hit to induce lung inflammation, followed 24 h later by a second hit of mechanical ventilation (MV) with either low tidal volume (6 mL/kg) with 5 cmH(2)O of positive end-expiratory pressure (PEEP) or high tidal volume (22 mL/kg) with zero PEEP for 4 h. GLN or lactated Ringer's solution as the placebo was administered intravenously 15 min prior to MV. Results: In the LPS-challenged rats ventilated with high tidal volume, the treatment with GLN improved lung injury indices, lung mechanics and cytokine responses compared with the placebo group. Conclusions: The administration of GLN given immediately prior to MV may be beneficial in the context of reducing VILI.
    關聯: Journal of Thoracic Disease, v.6 n.12, pp.1704-1713
    显示于类别:[休閒保健管理系(所)] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML868检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈