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    Title: The protective effects of glutamine in a rat model of ventilator-induced lung injury
    Authors: Chen, Chin-Ming
    Cheng, Kuo-Chen
    Li, Chien-Feng
    Zhang, Haibo
    Contributors: 休閒保健管理系
    Keywords: Acute respiratory distress syndrome (ARDS)
    mechanical ventilation (MV)
    glutamine (GLN)
    Date: 2014-12
    Issue Date: 2015-05-06 21:26:16 (UTC+8)
    Publisher: Pioneer Bioscience Publ Co
    Abstract: Background: The mortality rate of patients with acute respiratory distress syndrome (ARDS) is still high despite the use of protective ventilatory strategies. We sought to examine the pharmacological effects of glutamine (GLN) in a two-hit model of endotoxin-induced inflammation followed by ventilator-induced lung injury (VILI). We hypothesized that the administration of GLN ameliorates the VILI. Methods: Sprague-Dawley rats were anesthetized and given lipopolysaccharide (LPS) intratracheally as a first hit to induce lung inflammation, followed 24 h later by a second hit of mechanical ventilation (MV) with either low tidal volume (6 mL/kg) with 5 cmH(2)O of positive end-expiratory pressure (PEEP) or high tidal volume (22 mL/kg) with zero PEEP for 4 h. GLN or lactated Ringer's solution as the placebo was administered intravenously 15 min prior to MV. Results: In the LPS-challenged rats ventilated with high tidal volume, the treatment with GLN improved lung injury indices, lung mechanics and cytokine responses compared with the placebo group. Conclusions: The administration of GLN given immediately prior to MV may be beneficial in the context of reducing VILI.
    Relation: Journal of Thoracic Disease, v.6 n.12, pp.1704-1713
    Appears in Collections:[Dept. of Recreation and Health-Care Management] Periodical Articles

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