Synthesis and Characteristics of Poly(methyl methacrylate-co-methacrylic acid)/Poly(methacrylic acid-co-N-isopropylacrylamide) Thermosensitive Semi-Hollow Latex Particles and Their Application to Drug Carriers

doi:10.1002/pola.27411

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標題:	Synthesis and Characteristics of Poly(methyl methacrylate-co-methacrylic acid)/Poly(methacrylic acid-co-N-isopropylacrylamide) Thermosensitive Semi-Hollow Latex Particles and Their Application to Drug Carriers
作者:	Lee, Chia-Fen Hsu, Mei-Ling Chu, Chun-Hsun Wu, Tsung-Yuan
貢獻者:	化粧品應用與管理系
關鍵字:	core-shell polymers emulsion polymerization lower critical solubility temperature morphology semi-hollow latex particles soapless emulsion polymerization thermosensitive
日期:	2014-12
上傳時間:	2015-05-06 21:25:43 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	In this work, the poly(methyl methacrylate-co-methacrylic acid)/poly(methacrylic acid-co-N-isopropylacrylamide) thermosensitive composite semi-hollow latex particles was synthesized by three processes. The first process was to synthesize the poly(methyl methacrylate-co-methacrylic acid) (poly (MMA-MAA)) copolymer latex particles by the method of soapless emulsion polymerization. The second process was to polymerize methacrylic acid (MAA), N-isopropylacrylamide (NIPAAm), and crosslinking agent, N,N-methylenebisacrylamide, in the presence of poly(MMA-MAA) latex particles to form the linear poly(methyl methacrylate-co-methacrylic acid)/crosslinking poly(methacrylic acid-co-N-isopropylacrylamide) (poly(MMA-MAA)/poly(MAA-NIPAAm)) core-shell latex particles with solid structure. In the third process, part of the linear poly(MMA-MAA) core of core-shell latex particles was dissolved by ammonia to form the poly(MMA-MAA)/poly(MAA-NIPAAm) thermosensitive semi-hollow latex particles. The morphologies of the semi-hollow latex particles show that there is a hollow zone between the linear poly(MMA-MAA) core and the crosslinked poly(MAA-NIPAAm) shell. The crosslinking agent and shell composition significantly influenced the lower critical solution temperature of poly(MMA-MAA)/poly(MAA-NIPAAm) semi-hollow latex particles. Besides, the poly(MMA-MAA)/poly(MAA-NIPAAm) thermosensitive semi-hollow latex particles were used as carriers to load with the model drug, caffeine. The processes of caffeine loaded into the semi-hollow latex particles appeared four situations, which was different from that of solid latex particles. In addition, the phenomenon of caffeine released from the semi-hollow latex particles was obviously different from that of solid latex particles. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 3441-3451
關聯:	Journal of Polymer Science Part A-Polymer Chemistry, v.52 n.23, pp.3441-3451
顯示於類別:	[化妝品應用與管理系(所)] 期刊論文

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