Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28701
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    標題: Synthesis and Characteristics of Poly(methyl methacrylate-co-methacrylic acid)/Poly(methacrylic acid-co-N-isopropylacrylamide) Thermosensitive Semi-Hollow Latex Particles and Their Application to Drug Carriers
    作者: Lee, Chia-Fen
    Hsu, Mei-Ling
    Chu, Chun-Hsun
    Wu, Tsung-Yuan
    貢獻者: 化粧品應用與管理系
    關鍵字: core-shell polymers
    emulsion polymerization
    lower critical solubility temperature
    semi-hollow latex particles
    soapless emulsion polymerization
    日期: 2014-12
    上傳時間: 2015-05-06 21:25:43 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: In this work, the poly(methyl methacrylate-co-methacrylic acid)/poly(methacrylic acid-co-N-isopropylacrylamide) thermosensitive composite semi-hollow latex particles was synthesized by three processes. The first process was to synthesize the poly(methyl methacrylate-co-methacrylic acid) (poly (MMA-MAA)) copolymer latex particles by the method of soapless emulsion polymerization. The second process was to polymerize methacrylic acid (MAA), N-isopropylacrylamide (NIPAAm), and crosslinking agent, N,N-methylenebisacrylamide, in the presence of poly(MMA-MAA) latex particles to form the linear poly(methyl methacrylate-co-methacrylic acid)/crosslinking poly(methacrylic acid-co-N-isopropylacrylamide) (poly(MMA-MAA)/poly(MAA-NIPAAm)) core-shell latex particles with solid structure. In the third process, part of the linear poly(MMA-MAA) core of core-shell latex particles was dissolved by ammonia to form the poly(MMA-MAA)/poly(MAA-NIPAAm) thermosensitive semi-hollow latex particles. The morphologies of the semi-hollow latex particles show that there is a hollow zone between the linear poly(MMA-MAA) core and the crosslinked poly(MAA-NIPAAm) shell. The crosslinking agent and shell composition significantly influenced the lower critical solution temperature of poly(MMA-MAA)/poly(MAA-NIPAAm) semi-hollow latex particles. Besides, the poly(MMA-MAA)/poly(MAA-NIPAAm) thermosensitive semi-hollow latex particles were used as carriers to load with the model drug, caffeine. The processes of caffeine loaded into the semi-hollow latex particles appeared four situations, which was different from that of solid latex particles. In addition, the phenomenon of caffeine released from the semi-hollow latex particles was obviously different from that of solid latex particles. (c) 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 3441-3451
    關聯: Journal of Polymer Science Part A-Polymer Chemistry, v.52 n.23, pp.3441-3451
    显示于类别:[化妝品應用與管理系(所)] 期刊論文


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