Simple synthesis, self-assembly, and cytotoxicity of novel dimeric cholesterol derivatives

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/28697

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標題:	Simple synthesis, self-assembly, and cytotoxicity of novel dimeric cholesterol derivatives
作者:	Chou, Tzung-Han Chen, Chien-Wen Liang, Chia-Hua Yeh, Li-Hsien Qian, Shizhi
貢獻者:	化粧品應用與管理系
關鍵字:	Dimeric cholesteryl derivatives Self-assembly Nano-structural aggregates Cytotoxicity HaCaT cells
日期:	2014-04
上傳時間:	2015-05-06 21:25:33 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	A simple and economic methodology to synthesize three types of novel dimeric cholesterol derivatives (DCDs) was developed. Results obtained from dynamic light scattering and transmission electron microscopy show that spherical and/or angular nano-structural aggregates of DCDs are formed by self-assembly in aqueous solution. The size and morphology of DCD dispersions depend on the spatial arrangement of the substituents and polarity of the head group in the DCD structures. The cytoxicity of DCD dispersions to human keratinocytes (HaCaT) and squamous cell carcinomas (SCC25) cells was also evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The present novel DCD dispersions were not toxic to HaCaT and SCC25 cells at appropriate tested concentrations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
關聯:	Colloids and Surfaces B-Biointerfaces, v.116, pp.153-159
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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