Simple synthesis, self-assembly, and cytotoxicity of novel dimeric cholesterol derivatives

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Title:	Simple synthesis, self-assembly, and cytotoxicity of novel dimeric cholesterol derivatives
Authors:	Chou, Tzung-Han Chen, Chien-Wen Liang, Chia-Hua Yeh, Li-Hsien Qian, Shizhi
Contributors:	化粧品應用與管理系
Keywords:	Dimeric cholesteryl derivatives Self-assembly Nano-structural aggregates Cytotoxicity HaCaT cells
Date:	2014-04
Issue Date:	2015-05-06 21:25:33 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	A simple and economic methodology to synthesize three types of novel dimeric cholesterol derivatives (DCDs) was developed. Results obtained from dynamic light scattering and transmission electron microscopy show that spherical and/or angular nano-structural aggregates of DCDs are formed by self-assembly in aqueous solution. The size and morphology of DCD dispersions depend on the spatial arrangement of the substituents and polarity of the head group in the DCD structures. The cytoxicity of DCD dispersions to human keratinocytes (HaCaT) and squamous cell carcinomas (SCC25) cells was also evaluated by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The present novel DCD dispersions were not toxic to HaCaT and SCC25 cells at appropriate tested concentrations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
Relation:	Colloids and Surfaces B-Biointerfaces, v.116, pp.153-159
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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