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https://ir.cnu.edu.tw/handle/310902800/28692
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| 標題: | Self-focusing Au@SiO2 nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection |
| 作者: | Quyen, Tran Thi Bich
Chang, Chun-Chao
Su, Wei-Nien
Uen, Yih-Huei
Pan, Chun-Jern
Liu, Jyong-Yue
Rick, John
Lin, Kai-Yuan
Hwang, Bing-Joe |
| 貢獻者: | 生物科技系 |
| 關鍵字: | ENHANCED RAMAN-SCATTERING
SEMICONDUCTOR QUANTUM DOTS
GOLD NANORODS
SILICA NANOPARTICLES
LIVING CELLS
LUNG-CANCER
LIVE CELLS
SURFACE
NANOCRYSTALS
CEA |
| 日期: | 2014 |
| 上傳時間: | 2015-05-06 21:25:21 (UTC+8) |
| 出版者: | Royal Soc Chemistry |
| 摘要: | A highly sensitive self-focusing surface-enhanced Raman scattering (SERS) methodology has been developed using Au@SiO2 core-shell nanorods for carcinoembryonic antigen (CEA) detection. The SERS enhancement factor was evaluated for anisotropic Au@SiO2 nanorods with silica shells of various thicknesses, upon which Rhodamine 6G (R6G) dye was applied as a reporter molecule for the quantitative determination of CEA. The highest R6G signal was attained with a silica layer of 1-2 nm thickness. The self-focusing character originates from the antibody-antigen interaction, which facilitates the SERS probes assembly and significantly increases the detection sensitivity of the CEA. Our results show that the SERS technique is able to detect CEA within a wide concentration range. With an extremely low limit of detection (LOD) of 0.86 fg mL(-1), the Au@SiO2 nanoprobes potentially enable the early diagnosis of cancer. Our work offers a low-cost route to the fabrication of sensing devices able to be used for monitoring cancer progression in natural matrices, such as blood. |
| 關聯: | Journal of Materials Chemistry B, v.2 n.6, pp.629-636 |
| 显示于类别: | [生物科技系(所)] 期刊論文
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