Self-focusing Au@SiO2 nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection

doi:10.1039/c3tb21278e

CNU IR > Pharmacy and Science > Dept. of Biotechnology (including master's program) > Periodical Articles > Item 310902800/28692

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28692

Title:	Self-focusing Au@SiO2 nanorods with rhodamine 6G as highly sensitive SERS substrate for carcinoembryonic antigen detection
Authors:	Quyen, Tran Thi Bich Chang, Chun-Chao Su, Wei-Nien Uen, Yih-Huei Pan, Chun-Jern Liu, Jyong-Yue Rick, John Lin, Kai-Yuan Hwang, Bing-Joe
Contributors:	生物科技系
Keywords:	ENHANCED RAMAN-SCATTERING SEMICONDUCTOR QUANTUM DOTS GOLD NANORODS SILICA NANOPARTICLES LIVING CELLS LUNG-CANCER LIVE CELLS SURFACE NANOCRYSTALS CEA
Date:	2014
Issue Date:	2015-05-06 21:25:21 (UTC+8)
Publisher:	Royal Soc Chemistry
Abstract:	A highly sensitive self-focusing surface-enhanced Raman scattering (SERS) methodology has been developed using Au@SiO2 core-shell nanorods for carcinoembryonic antigen (CEA) detection. The SERS enhancement factor was evaluated for anisotropic Au@SiO2 nanorods with silica shells of various thicknesses, upon which Rhodamine 6G (R6G) dye was applied as a reporter molecule for the quantitative determination of CEA. The highest R6G signal was attained with a silica layer of 1-2 nm thickness. The self-focusing character originates from the antibody-antigen interaction, which facilitates the SERS probes assembly and significantly increases the detection sensitivity of the CEA. Our results show that the SERS technique is able to detect CEA within a wide concentration range. With an extremely low limit of detection (LOD) of 0.86 fg mL(-1), the Au@SiO2 nanoprobes potentially enable the early diagnosis of cancer. Our work offers a low-cost route to the fabrication of sensing devices able to be used for monitoring cancer progression in natural matrices, such as blood.
Relation:	Journal of Materials Chemistry B, v.2 n.6, pp.629-636
Appears in Collections:	[Dept. of Biotechnology (including master's program)] Periodical Articles

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