Risk of second primary malignancies after nasopharyngeal carcinoma: A population-based cohort study in Taiwan

doi:10.1002/hed.23281

Chia Nan University of Pharmacy & Science Institutional Repository > 智慧生活學院 > 醫務管理系(所) > 期刊論文 > Item 310902800/28682

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標題:	Risk of second primary malignancies after nasopharyngeal carcinoma: A population-based cohort study in Taiwan
作者:	Lin, Charlene Lin, Shih-Wei Weng, Shih-Feng Lin, Yung-Song
貢獻者:	醫務管理系
關鍵字:	nasopharyngeal carcinoma second primary malignancy cancer survival oropharyngeal carcinoma oral cancer
日期:	2014-02
上傳時間:	2015-05-06 21:25:01 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	BackgroundThe purpose of this study was to examine the risk of second primary malignancy (SPM) after nasopharyngeal carcinoma (NPC). MethodsWe compared the incidence of SPM in patients diagnosed with NPC at the end of 2009 using the data extracted from the Taiwan Longitudinal Health Insurance Database between 2001 and 2008 (n = 10,299), with age-matched controls (1:10; n = 102,990). ResultsWe found a 55% increased risk of SPM in patients diagnosed with NPC, compared to the risk of first malignancy in the age-matched controls (incidence rate ratio [IRR] = 1.55; p < .0001). Although the diagnosis of SPM was negatively correlated with the survival of patients with NPC (p = .0011), primary NPC did not display any synergic effect on the survival of patients with SPM, compared to age-matched controls with a newly diagnosed malignancy (p = .8986). ConclusionNPC is associated with an increased risk of developing an SPM. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 209-214, 2014
關聯:	Head and Neck-Journal For the Sciences and Specialties of the Head and Neck, v.36 n.2, pp.209-214
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