Risk of second primary malignancies after nasopharyngeal carcinoma: A population-based cohort study in Taiwan

doi:10.1002/hed.23281

CNU IR > College of Smart Living > Dept. of Hospital and Health (including master's program) > Periodical Articles > Item 310902800/28682

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28682

Title:	Risk of second primary malignancies after nasopharyngeal carcinoma: A population-based cohort study in Taiwan
Authors:	Lin, Charlene Lin, Shih-Wei Weng, Shih-Feng Lin, Yung-Song
Contributors:	醫務管理系
Keywords:	nasopharyngeal carcinoma second primary malignancy cancer survival oropharyngeal carcinoma oral cancer
Date:	2014-02
Issue Date:	2015-05-06 21:25:01 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	BackgroundThe purpose of this study was to examine the risk of second primary malignancy (SPM) after nasopharyngeal carcinoma (NPC). MethodsWe compared the incidence of SPM in patients diagnosed with NPC at the end of 2009 using the data extracted from the Taiwan Longitudinal Health Insurance Database between 2001 and 2008 (n = 10,299), with age-matched controls (1:10; n = 102,990). ResultsWe found a 55% increased risk of SPM in patients diagnosed with NPC, compared to the risk of first malignancy in the age-matched controls (incidence rate ratio [IRR] = 1.55; p < .0001). Although the diagnosis of SPM was negatively correlated with the survival of patients with NPC (p = .0011), primary NPC did not display any synergic effect on the survival of patients with SPM, compared to age-matched controls with a newly diagnosed malignancy (p = .8986). ConclusionNPC is associated with an increased risk of developing an SPM. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 209-214, 2014
Relation:	Head and Neck-Journal For the Sciences and Specialties of the Head and Neck, v.36 n.2, pp.209-214
Appears in Collections:	[Dept. of Hospital and Health (including master's program)] Periodical Articles

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