English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18034/20233 (89%)
造訪人次 : 23343755      線上人數 : 491
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/28640


    標題: Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
    作者: Lee, Sung-Wei
    Lin, Ching-Yih
    Tian, Yu-Feng
    Sun, Ding-Ping
    Lin, Li-Ching
    Chen, Li-Tzong
    Hsing, Chung-Hsi
    Huang, Chiang-Ting
    Hsu, Han-Ping
    Huang, Hsuan-Ying
    Wu, Li-Ching
    Li, Chien-Feng
    Shiue, Yow-Ling
    貢獻者: 保健營養系
    關鍵字: Nasopharyngeal carcinoma
    CDC28 protein kinase regulatory subunit 1B
    CKS1B
    survival
    日期: 2014-03
    上傳時間: 2015-05-06 21:23:30 (UTC+8)
    出版者: Wiley-Blackwell
    摘要: Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p=0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p<0.001), metastasis-free survival (p<0.001), and local recurrence-free survival (p=0.001). High expression of CKS1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin-dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.
    關聯: Apmis, v.122 n.3, pp.206-214
    顯示於類別:[保健營養系(所) ] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML1374檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋