Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma

doi:10.1111/apm.12136

CNU IR > Pharmacy and Science > Dept. of Health and Nutrition (including master's program) > Periodical Articles > Item 310902800/28640

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28640

Title:	Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
Authors:	Lee, Sung-Wei Lin, Ching-Yih Tian, Yu-Feng Sun, Ding-Ping Lin, Li-Ching Chen, Li-Tzong Hsing, Chung-Hsi Huang, Chiang-Ting Hsu, Han-Ping Huang, Hsuan-Ying Wu, Li-Ching Li, Chien-Feng Shiue, Yow-Ling
Contributors:	保健營養系
Keywords:	Nasopharyngeal carcinoma CDC28 protein kinase regulatory subunit 1B CKS1B survival
Date:	2014-03
Issue Date:	2015-05-06 21:23:30 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	Data mining on public domain identified that CDC28 protein kinase regulatory subunit 1B (CKS1B) transcript was highly expressed in nasopharyngeal carcinoma (NPC). The expression of CKS1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer (AJCC) stage (p=0.014). In multivariate analyses, high CKS1B expression emerged as an independent prognostic factor for worse disease-specific survival (p<0.001), metastasis-free survival (p<0.001), and local recurrence-free survival (p=0.001). High expression of CKS1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin-dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.
Relation:	Apmis, v.122 n.3, pp.206-214
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles

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