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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/28632


    標題: Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan
    作者: Chen, Yu-Li
    Weng, Shih-Feng
    Shen, Yuan-Chi
    Chou, Chien-Wen
    Yang, Chwen-Yi
    Wang, Jhi-Joung
    Tien, Kai-Jen
    貢獻者: 醫務管理系
    通識教育中心
    關鍵字: OXYGEN-TENSION
    BONE-RESORPTION
    HYPOXIA
    HEALTH
    INCREASES
    ASSOCIATION
    DISEASES
    INVITRO
    OBESITY
    MARROW
    日期: 2014-07
    上傳時間: 2015-05-06 21:23:14 (UTC+8)
    出版者: Endocrine Soc
    摘要: Background: Obstructive sleep apnea (OSA) is associated with metabolic, endocrine, and cardiovascular diseases. It is characterized by repetitive episodes of apnea/hypopnea and hypoxia in tissues, which might also impact bone metabolism. This study investigates the possible association between OSA and osteoporosis. Methods: Random samples of 1 million individuals were collected from Taiwan's National Health Insurance database. A total of 1377 patients with newly diagnosed OSA from 2000 to 2008 were recruited and compared with a matched cohort of 20 655 patients without OSA. All patients were tracked until an osteoporosis diagnosis, death, or the end of 2011. Results: During the 6-year follow-up period, the incidence rates of osteoporosis in the OSA cohort and comparison group were 2.52 and 1.00 per 1000 person-years, respectively. Patients with OSA were found to be at 2.74 times the risk of osteoporosis than patients without OSA (95% confidence interval 1.69-4.44, P < .05), after adjustment for age, gender, diabetes, hypertension, coronary artery disease, obesity, stroke, hyperlipidemia, chronic kidney disease, gout, monthly income, and geographical location. Subgroup analysis showed that older patients and female patients had a higher risk for osteoporosis than their younger and male counterparts. Log-rank analysis revealed that patients with OSA patients had significantly higher cumulative incidence rates of osteoporosis than the comparison group (P < .0001). Conclusion: People diagnosed with OSA are at increased risk for subsequent osteoporosis.
    關聯: Journal of Clinical Endocrinology & Metabolism, v.99 n.7, pp.2441-2447
    Appears in Collections:[通識教育中心] 期刊論文
    [醫務管理系(所)] 期刊論文

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