Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan

doi:10.1210/jc.2014-1718

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標題:	Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan
作者:	Chen, Yu-Li Weng, Shih-Feng Shen, Yuan-Chi Chou, Chien-Wen Yang, Chwen-Yi Wang, Jhi-Joung Tien, Kai-Jen
貢獻者:	醫務管理系通識教育中心
關鍵字:	OXYGEN-TENSION BONE-RESORPTION HYPOXIA HEALTH INCREASES ASSOCIATION DISEASES INVITRO OBESITY MARROW
日期:	2014-07
上傳時間:	2015-05-06 21:23:14 (UTC+8)
出版者:	Endocrine Soc
摘要:	Background: Obstructive sleep apnea (OSA) is associated with metabolic, endocrine, and cardiovascular diseases. It is characterized by repetitive episodes of apnea/hypopnea and hypoxia in tissues, which might also impact bone metabolism. This study investigates the possible association between OSA and osteoporosis. Methods: Random samples of 1 million individuals were collected from Taiwan's National Health Insurance database. A total of 1377 patients with newly diagnosed OSA from 2000 to 2008 were recruited and compared with a matched cohort of 20 655 patients without OSA. All patients were tracked until an osteoporosis diagnosis, death, or the end of 2011. Results: During the 6-year follow-up period, the incidence rates of osteoporosis in the OSA cohort and comparison group were 2.52 and 1.00 per 1000 person-years, respectively. Patients with OSA were found to be at 2.74 times the risk of osteoporosis than patients without OSA (95% confidence interval 1.69-4.44, P < .05), after adjustment for age, gender, diabetes, hypertension, coronary artery disease, obesity, stroke, hyperlipidemia, chronic kidney disease, gout, monthly income, and geographical location. Subgroup analysis showed that older patients and female patients had a higher risk for osteoporosis than their younger and male counterparts. Log-rank analysis revealed that patients with OSA patients had significantly higher cumulative incidence rates of osteoporosis than the comparison group (P < .0001). Conclusion: People diagnosed with OSA are at increased risk for subsequent osteoporosis.
關聯:	Journal of Clinical Endocrinology & Metabolism, v.99 n.7, pp.2441-2447
显示于类别:	[通識教育中心] 期刊論文 [醫務管理系(所)] 期刊論文

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