Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28630
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    標題: Nontuberculosis Mycobacterium Disease is a Risk Factor for Chronic Obstructive Pulmonary Disease: A Nationwide Cohort Study
    作者: Yeh, Jun-Jun
    Wang, Yu-Chiao
    Sung, Fung-Chang
    Chou, Christine Yi-Ting
    Kao, Chia-Hung
    貢獻者: 嬰幼兒保育系
    關鍵字: Chronic obstructive pulmonary disease
    Nontuberculosis mycobacterium diseases
    National Health Insurance Research Database
    日期: 2014-06
    上傳時間: 2015-05-06 21:23:10 (UTC+8)
    出版者: Springer
    摘要: The aim of this study was to evaluate the association between chronic obstructive pulmonary disease (COPD) and nontuberculosis mycobacterium (NTM) disease. We used data from the National Health Insurance Research Database of Taiwan in this study. The NTM cohort contained 3,005 patients, and each case was randomly frequency matched by age, sex, income, occupation, and index year with four people from the general population without NTM infections. Multivariate Cox proportional hazards regression was used to calculate adjusted hazard ratios (aHR) of COPD in the NTM cohort compared with the non-NTM cohort. The incidence of COPD was 3.08-fold higher (21.75 vs. 6.11 per 1,000 person-years) in the NTM cohort than in the non-NTM cohort. The aHR of COPD comparing the NTM cohort with the non-NTM cohort was 3.57 (95 % CI 2.56-4.97) for women and 2.89 (95 % CI 2.31-3.61) for men. The aHR of COPD was higher in the patients with NTM infection and a comorbidity such as bronchopneumonia, pneumonia, diabetes, asthma, and heart disease. The Mycobacterium avium-intracellulare complex group (MAC) and the non-MAC group were isolated in the NTM cohort. The MAC group had a higher aHR of COPD than the non-NTM cohort (aHR = 3.72, 95 % CI 2.94-4.72). The cumulative incidence of COPD in the NTM cohort was higher than in the non-NTM cohort (P < 0.0001, log rank test). Physicians should be aware of indolent NTM disease that increases the risk of COPD.
    關聯: Lung, v.192 n.3, pp.403-411
    顯示於類別:[嬰幼兒保育系] 期刊論文

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