Identification of the first imported KPC-3 Klebsiella pneumoniae from the USA to Taiwan

doi:10.1016/j.ijantimicag.2014.07.009

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 保健營養系(所) > 期刊論文 > Item 310902800/28597

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標題:	Identification of the first imported KPC-3 Klebsiella pneumoniae from the USA to Taiwan
作者:	Tang, Hung-Jen Chen, Ying-Tsong Chiang, Tom Fung, Chang-Phone Chuang, Yin-Ching Siu, L. Kristopher
貢獻者:	保健營養系
關鍵字:	KPC-3, Klebsiella pneumoniae Taiwan
日期:	2014-11
上傳時間:	2015-05-06 21:21:59 (UTC+8)
出版者:	Elsevier Science Bv
摘要:	Establishment of KPC-associated genes into a new region usually requires travellers with hospital admission and their carriage into the communities. In this report, a worldwide spreading clone carrying KPC-3 was isolated from the sputum of a hospitalised patient with a serious infection who had just come from the USA and had been admitted to a New York hospital. By genetic comparison with a strain isolated from New Jersey (NJ-KPC-21), this isolate from the traveller was genetically related. The bla(KPC-3) gene was harboured on a large plasmid with a complex structure of a Tn3-based transposon, Tn4401a. The KPC-3-carrying plasmid was very similar (>99.9% identity) to the 113 637-bp bla(KPC-3)-encoding plasmid pKpQIL that originated from the 2006 epidemic carbapenem-resistant Klebsiella pneumoniae outbreak in Israel. With the first recognition of KPC-2 in 2011 and continuing spread, physicians should be aware of the coming of KPC-3 K. pneumoniae in Taiwan. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
關聯:	International Journal of Antimicrobial Agents, v.44 n.5, pp.431-435
顯示於類別:	[保健營養系(所) ] 期刊論文

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