Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28597
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    標題: Identification of the first imported KPC-3 Klebsiella pneumoniae from the USA to Taiwan
    作者: Tang, Hung-Jen
    Chen, Ying-Tsong
    Chiang, Tom
    Fung, Chang-Phone
    Chuang, Yin-Ching
    Siu, L. Kristopher
    貢獻者: 保健營養系
    關鍵字: KPC-3, Klebsiella pneumoniae
    日期: 2014-11
    上傳時間: 2015-05-06 21:21:59 (UTC+8)
    出版者: Elsevier Science Bv
    摘要: Establishment of KPC-associated genes into a new region usually requires travellers with hospital admission and their carriage into the communities. In this report, a worldwide spreading clone carrying KPC-3 was isolated from the sputum of a hospitalised patient with a serious infection who had just come from the USA and had been admitted to a New York hospital. By genetic comparison with a strain isolated from New Jersey (NJ-KPC-21), this isolate from the traveller was genetically related. The bla(KPC-3) gene was harboured on a large plasmid with a complex structure of a Tn3-based transposon, Tn4401a. The KPC-3-carrying plasmid was very similar (>99.9% identity) to the 113 637-bp bla(KPC-3)-encoding plasmid pKpQIL that originated from the 2006 epidemic carbapenem-resistant Klebsiella pneumoniae outbreak in Israel. With the first recognition of KPC-2 in 2011 and continuing spread, physicians should be aware of the coming of KPC-3 K. pneumoniae in Taiwan. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
    關聯: International Journal of Antimicrobial Agents, v.44 n.5, pp.431-435
    显示于类别:[保健營養系(所) ] 期刊論文


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