Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28591
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    標題: High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion
    作者: Chen, Yu-Wen
    Tzeng, Jann-Inn
    Lin, Min-Fei
    Hung, Ching-Hsia
    Hsieh, Pei-Ling
    Wang, Jhi-Joung
    貢獻者: 食品科技系
    關鍵字: PRIMARY SENSORY NEURONS
    TENS-INDUCED ANTIHYPERALGESIA
    GENE-RELATED PEPTIDE
    NEUROPATHIC PAIN
    POSTOPERATIVE PAIN
    PROTEIN-KINASE
    SCIATIC-NERVE
    MECHANICAL ALLODYNIA
    DIABETIC-NEUROPATHY
    THERMAL SENSITIVITY
    日期: 2014-07
    上傳時間: 2015-05-06 21:21:47 (UTC+8)
    出版者: Lippincott Williams & Wilkins
    摘要: Background: Transcutaneous electrical nerve stimulation (TENS) is a common therapeutic modality for pain management, but its effectiveness in skin/muscle incision and retraction (SMIR)-evoked pain is unknown. We aimed to examine the effects of TENS on postoperative pain and the levels of substance P (SP), N-methyl-D-aspartate receptor 1 (NR1), and interleukin 1 beta (IL-1 beta) in rat dorsal root ganglion (DRG). Methods: High-frequency (100 Hz) TENS was administered daily beginning on postoperative day 1 (POD1) and continued until animal subjects were killed for tissues. Mechanical sensitivity to von Frey stimuli (6g and 15g) and the levels of NR1, SP, and IL-1 beta in DRG were assessed in the sham-operated, SMIR-operated, TENS after SMIR surgery, and placebo-TENS after SMIR surgery groups. Results: Skin/muscle incision and retraction rats exhibited a significant hypersensitivity to von Frey stimuli on POD3. In contrast with SMIR rats, SMIR-operated rats receiving TENS therapy demonstrated a rapid recovery of mechanical hypersensitivity. The SMIR-operated rats showed an up-regulation of NR1, SP, and IL-1 beta in DRG on PODs 14 and 28, whereas the SMIR-operated rats after TENS administration reversed this up-regulation. By contrast, the placebo-TENS after SMIR operation did not alter postsurgical pain nor the levels of NR1, SP, and IL-1 beta. Conclusions: Our data demonstrated that TENS intervention reduced persistent postoperative pain caused by SMIR operation. Up-regulation of NR1, SP, and IL-1 beta in DRG, activated after SMIR surgery, is important in the development of prolonged postincisional pain. The TENS pain relief may be related to the suppression of NR1, SP, and IL-1 beta in DRG of SMIR rats.
    關聯: Regional Anesthesia and Pain Medicine, v.39 n.4, pp.322-328
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