High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion

doi:10.1097/AAP.0000000000000091

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/28591

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Title:	High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion
Authors:	Chen, Yu-Wen Tzeng, Jann-Inn Lin, Min-Fei Hung, Ching-Hsia Hsieh, Pei-Ling Wang, Jhi-Joung
Contributors:	食品科技系
Keywords:	PRIMARY SENSORY NEURONS TENS-INDUCED ANTIHYPERALGESIA GENE-RELATED PEPTIDE NEUROPATHIC PAIN POSTOPERATIVE PAIN PROTEIN-KINASE SCIATIC-NERVE MECHANICAL ALLODYNIA DIABETIC-NEUROPATHY THERMAL SENSITIVITY
Date:	2014-07
Issue Date:	2015-05-06 21:21:47 (UTC+8)
Publisher:	Lippincott Williams & Wilkins
Abstract:	Background: Transcutaneous electrical nerve stimulation (TENS) is a common therapeutic modality for pain management, but its effectiveness in skin/muscle incision and retraction (SMIR)-evoked pain is unknown. We aimed to examine the effects of TENS on postoperative pain and the levels of substance P (SP), N-methyl-D-aspartate receptor 1 (NR1), and interleukin 1 beta (IL-1 beta) in rat dorsal root ganglion (DRG). Methods: High-frequency (100 Hz) TENS was administered daily beginning on postoperative day 1 (POD1) and continued until animal subjects were killed for tissues. Mechanical sensitivity to von Frey stimuli (6g and 15g) and the levels of NR1, SP, and IL-1 beta in DRG were assessed in the sham-operated, SMIR-operated, TENS after SMIR surgery, and placebo-TENS after SMIR surgery groups. Results: Skin/muscle incision and retraction rats exhibited a significant hypersensitivity to von Frey stimuli on POD3. In contrast with SMIR rats, SMIR-operated rats receiving TENS therapy demonstrated a rapid recovery of mechanical hypersensitivity. The SMIR-operated rats showed an up-regulation of NR1, SP, and IL-1 beta in DRG on PODs 14 and 28, whereas the SMIR-operated rats after TENS administration reversed this up-regulation. By contrast, the placebo-TENS after SMIR operation did not alter postsurgical pain nor the levels of NR1, SP, and IL-1 beta. Conclusions: Our data demonstrated that TENS intervention reduced persistent postoperative pain caused by SMIR operation. Up-regulation of NR1, SP, and IL-1 beta in DRG, activated after SMIR surgery, is important in the development of prolonged postincisional pain. The TENS pain relief may be related to the suppression of NR1, SP, and IL-1 beta in DRG of SMIR rats.
Relation:	Regional Anesthesia and Pain Medicine, v.39 n.4, pp.322-328
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles

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