Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration

doi:10.3390/nu6083101

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/28587

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標題:	Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration
作者:	Lai, Chih-Cheng Liu, Wei-Lun Chen, Chin-Ming
貢獻者:	休閒保健管理系
關鍵字:	acid aspiration ARDS glutamine ventilator-induced lung injury
日期:	2014-08
上傳時間:	2015-05-06 21:21:38 (UTC+8)
出版者:	Mdpi Ag
摘要:	Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer's solution (vehicle control) thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory.
關聯:	Nutrients, v.6 n.8, pp.3101-3116
顯示於類別:	[休閒保健管理系(所)] 期刊論文

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