Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration

doi:10.3390/nu6083101

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/28587

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28587

Title:	Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration
Authors:	Lai, Chih-Cheng Liu, Wei-Lun Chen, Chin-Ming
Contributors:	休閒保健管理系
Keywords:	acid aspiration ARDS glutamine ventilator-induced lung injury
Date:	2014-08
Issue Date:	2015-05-06 21:21:38 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer's solution (vehicle control) thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory.
Relation:	Nutrients, v.6 n.8, pp.3101-3116
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

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