Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28571
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    標題: Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells
    作者: Wang, Wen-Hung
    Tyan, Yu-Chang
    Chen, Zong-Shiow
    Lin, Ching-Gong
    Yang, Ming-Hui
    Yuan, Shyng-Shiou
    Tsai, Wan-Chi
    貢獻者: 化粧品應用與管理系
    關鍵字: APOPTOSIS
    SURVIVIN
    CANCER
    FRUITS
    ACID
    ANTHOCYANINS
    PROTEINS
    CLEAVAGE
    RELEASE
    PATHWAY
    日期: 2014
    上傳時間: 2015-05-06 21:21:06 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties. In this study, the antiproliferative activity of extracts from different parts of the jaboticaba (Myrciaria cauliflora) plant was evaluated for its effect on human oral carcinoma cell lines. The cytotoxicities of various plant extract concentrations were examined and the 50% maximal inhibitory concentration (IC50) was determined. Water extracts of jaboticaba seeds showed concentration-dependent antiproliferative effects. Annexin V/propidium iodide positivity with active caspase-3 induction indicated that the treated cells underwent apoptosis. Several important regulatory proteins (Bcl-2, Bcl-xL, Bid, and survivin) involved in apoptosis were also evaluated. The antioxidant activity of jaboticaba was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the drug concentration eliciting 50% maximum stimulation (SC50) was determined. The present findings suggest that water extracts of jaboticaba seeds exhibit an antiproliferative effect against oral cancer cells by inducing apoptosis through downregulating survivin expression and thereby activating caspase-mediated Bid cleavage.
    關聯: Biomed Research International, 185946
    显示于类别:[化妝品應用與管理系(所)] 期刊論文

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