Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells

doi:10.1155/2014/185946

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/28571

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题名:	Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells
作者:	Wang, Wen-Hung Tyan, Yu-Chang Chen, Zong-Shiow Lin, Ching-Gong Yang, Ming-Hui Yuan, Shyng-Shiou Tsai, Wan-Chi
贡献者:	化粧品應用與管理系
关键词:	APOPTOSIS SURVIVIN CANCER FRUITS ACID ANTHOCYANINS PROTEINS CLEAVAGE RELEASE PATHWAY
日期:	2014
上传时间:	2015-05-06 21:21:06 (UTC+8)
出版者:	Hindawi Publishing Corporation
摘要:	It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties. In this study, the antiproliferative activity of extracts from different parts of the jaboticaba (Myrciaria cauliflora) plant was evaluated for its effect on human oral carcinoma cell lines. The cytotoxicities of various plant extract concentrations were examined and the 50% maximal inhibitory concentration (IC50) was determined. Water extracts of jaboticaba seeds showed concentration-dependent antiproliferative effects. Annexin V/propidium iodide positivity with active caspase-3 induction indicated that the treated cells underwent apoptosis. Several important regulatory proteins (Bcl-2, Bcl-xL, Bid, and survivin) involved in apoptosis were also evaluated. The antioxidant activity of jaboticaba was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the drug concentration eliciting 50% maximum stimulation (SC50) was determined. The present findings suggest that water extracts of jaboticaba seeds exhibit an antiproliferative effect against oral cancer cells by inducing apoptosis through downregulating survivin expression and thereby activating caspase-mediated Bid cleavage.
關聯:	Biomed Research International, 185946
显示于类别:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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