Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice

doi:10.1016/j.fct.2014.04.008

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標題:	Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice
作者:	Wang, Hsien-Yi Kan, Wei-Chih Cheng, Tain-Junn Yu, Sung-Hsun Chang, Liang-Hao Chuu, Jiunn-Jye
貢獻者:	運動管理系職業安全衛生系
關鍵字:	Momordica charantia Charantin Type 2 diabetes Hypoglycemic Insulin signaling Pancreatic beta cells
日期:	2014-07
上傳時間:	2015-05-06 21:20:02 (UTC+8)
出版者:	Pergamon-Elsevier Science Ltd
摘要:	Momordica charantia Linn. (Cucurbitaceae), also called bitter melon, has traditionally been used as a natural anti-diabetic agent for anti-hyperglycemic activity in several animal models and clinical trials. We investigated the differences in the anti-diabetic properties and mechanism of action of Taiwanese M. charantia (MC) between type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. To clarify the beneficial effects of MC, we measured non-fasting glucose, oral glucose tolerance, and plasma insulin levels in KK/HIJ mice with high-fat diet-induced diabetes (200 mg/kg/day of charantin-rich extract of MC [CEMC]) and in ICR mice with STZ-induced diabetes. After 8 weeks, all the mice were exsanguinated, and the expression of the insulin-signaling-associated proteins in their tissue was evaluated, in coordination with the protective effects of CEMC against pancreatic beta-cell toxicity (in vitro). Eight weeks of data indicated that CEMC caused a significant decline in non-fasting blood glucose, plasma glucose intolerance, and insulin resistance in the KK/HIJ mice, but not in the ICR mice. Furthermore, CEMC decreased plasma insulin and promoted the sensitivity of insulin by increasing the expression of GLUT4 in the skeletal muscle and of IRS-1 in the liver of KK/HIJ mice; however, CEMC extract had no effect on the insulin sensitivity of ICR mice. In vitro study showed that CEMC prevented pancreatic beta cells from high-glucose-induced cytotoxicity after 24 h of incubation, but the protective effect was not detectable after 72 h. Collectively, the hypoglycemic effects of CEMC suggest that it has potential for increasing insulin sensitivity in patients with T2D rather than for protecting patients with T1D against beta-cell dysfunction. (C) 2014 Elsevier Ltd. All rights reserved.
關聯:	Food and Chemical Toxicology, v.69 n., pp.347-356
显示于类别:	[職業安全衛生系(含防災所)] 期刊論文 [運動管理系] 期刊論文

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