Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice

doi:10.1016/j.fct.2014.04.008

CNU IR > College of Sustainable Environment and Recreation > Dept. of Sports Management > Periodical Articles > Item 310902800/28542

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28542

Title:	Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice
Authors:	Wang, Hsien-Yi Kan, Wei-Chih Cheng, Tain-Junn Yu, Sung-Hsun Chang, Liang-Hao Chuu, Jiunn-Jye
Contributors:	運動管理系職業安全衛生系
Keywords:	Momordica charantia Charantin Type 2 diabetes Hypoglycemic Insulin signaling Pancreatic beta cells
Date:	2014-07
Issue Date:	2015-05-06 21:20:02 (UTC+8)
Publisher:	Pergamon-Elsevier Science Ltd
Abstract:	Momordica charantia Linn. (Cucurbitaceae), also called bitter melon, has traditionally been used as a natural anti-diabetic agent for anti-hyperglycemic activity in several animal models and clinical trials. We investigated the differences in the anti-diabetic properties and mechanism of action of Taiwanese M. charantia (MC) between type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. To clarify the beneficial effects of MC, we measured non-fasting glucose, oral glucose tolerance, and plasma insulin levels in KK/HIJ mice with high-fat diet-induced diabetes (200 mg/kg/day of charantin-rich extract of MC [CEMC]) and in ICR mice with STZ-induced diabetes. After 8 weeks, all the mice were exsanguinated, and the expression of the insulin-signaling-associated proteins in their tissue was evaluated, in coordination with the protective effects of CEMC against pancreatic beta-cell toxicity (in vitro). Eight weeks of data indicated that CEMC caused a significant decline in non-fasting blood glucose, plasma glucose intolerance, and insulin resistance in the KK/HIJ mice, but not in the ICR mice. Furthermore, CEMC decreased plasma insulin and promoted the sensitivity of insulin by increasing the expression of GLUT4 in the skeletal muscle and of IRS-1 in the liver of KK/HIJ mice; however, CEMC extract had no effect on the insulin sensitivity of ICR mice. In vitro study showed that CEMC prevented pancreatic beta cells from high-glucose-induced cytotoxicity after 24 h of incubation, but the protective effect was not detectable after 72 h. Collectively, the hypoglycemic effects of CEMC suggest that it has potential for increasing insulin sensitivity in patients with T2D rather than for protecting patients with T1D against beta-cell dysfunction. (C) 2014 Elsevier Ltd. All rights reserved.
Relation:	Food and Chemical Toxicology, v.69 n., pp.347-356
Appears in Collections:	[Dept. of Occupational Safety] Periodical Articles [Dept. of Sports Management] Periodical Articles

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