Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats

doi:10.3390/ijms151121299

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標題:	Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats
作者:	Liu, Chia-Chyuan Shih, Mei-Fen Wen, Yi-Szu Lai, Ying-Hsiu Yang, Tsai-Hsiu
貢獻者:	化粧品應用與管理系藥學系保健營養系
關鍵字:	heat stroke multiorgan dysfunction dexamethasone hypercoagulable state cytokines
日期:	2014-11
上傳時間:	2015-05-06 21:19:59 (UTC+8)
出版者:	Mdpi Ag
摘要:	Dexamethasone (DXM) is known as an immunosuppressive drug used for inflammation control. In the present study, we attempted to examine whether DXM administration could attenuate the hypercoagulable state and the overproduction of pro-inflammatory cytokines, improve arterial hypotension, cerebral ischemia and damage, and vital organ failure in a rat model of heat stroke. The results indicated that all the rats suffering from heat stroke showed high serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), accompanied with increased prothrombin time, activated partial thromboplastin time and D-D dimer, and decreased protein C. During the induction period of heat stroke, plasma levels of blood urea nitrogen (BUN), creatinine, glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT), and alkaline phosphatase (ALP), were consistently increased. High striatal levels of glycerol, glutamate, and lactate/pyruvate were simultaneously detected. On the contrary, the mean arterial pressure, plasma levels of interleukin-10 (IL-10), and local cerebral blood flow at the striatum were all decreased. Importantly, intravenous administration of DXM substantially ameliorated the circulatory dysfunction, systematic inflammation, hypercoagulable state, cerebral ischemia and damage during the induction period of heat stroke. These findings demonstrated that DXM may be an alternative therapy that can ameliorate heat stroke victims by attenuating activated coagulation, systemic inflammation, and vital organ ischemia/injury during heat stroke.
關聯:	International Journal of Molecular Sciences, v.15 n.11, pp.21299-21313
顯示於類別:	[保健營養系(所) ] 期刊論文 [藥學系(所)] 期刊論文 [化妝品應用與管理系(所)] 期刊論文

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