Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats

doi:10.3390/ijms151121299

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/28541

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28541

Title:	Dexamethasone Improves Heat Stroke-Induced Multiorgan Dysfunction and Damage in Rats
Authors:	Liu, Chia-Chyuan Shih, Mei-Fen Wen, Yi-Szu Lai, Ying-Hsiu Yang, Tsai-Hsiu
Contributors:	化粧品應用與管理系藥學系保健營養系
Keywords:	heat stroke multiorgan dysfunction dexamethasone hypercoagulable state cytokines
Date:	2014-11
Issue Date:	2015-05-06 21:19:59 (UTC+8)
Publisher:	Mdpi Ag
Abstract:	Dexamethasone (DXM) is known as an immunosuppressive drug used for inflammation control. In the present study, we attempted to examine whether DXM administration could attenuate the hypercoagulable state and the overproduction of pro-inflammatory cytokines, improve arterial hypotension, cerebral ischemia and damage, and vital organ failure in a rat model of heat stroke. The results indicated that all the rats suffering from heat stroke showed high serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), accompanied with increased prothrombin time, activated partial thromboplastin time and D-D dimer, and decreased protein C. During the induction period of heat stroke, plasma levels of blood urea nitrogen (BUN), creatinine, glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT), and alkaline phosphatase (ALP), were consistently increased. High striatal levels of glycerol, glutamate, and lactate/pyruvate were simultaneously detected. On the contrary, the mean arterial pressure, plasma levels of interleukin-10 (IL-10), and local cerebral blood flow at the striatum were all decreased. Importantly, intravenous administration of DXM substantially ameliorated the circulatory dysfunction, systematic inflammation, hypercoagulable state, cerebral ischemia and damage during the induction period of heat stroke. These findings demonstrated that DXM may be an alternative therapy that can ameliorate heat stroke victims by attenuating activated coagulation, systemic inflammation, and vital organ ischemia/injury during heat stroke.
Relation:	International Journal of Molecular Sciences, v.15 n.11, pp.21299-21313
Appears in Collections:	[Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Pharmacy] Periodical Articles [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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