Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28504
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    標題: Anti-Inflammatory Effect and Mechanism of the Green Fruit Extract of Solanum integrifolium Poir.
    作者: Wang, Lisu
    Chiou, Shu-Yuan
    Shen, Yi-Ting
    Yen, Fu-Tsun
    Ding, Hsiou-Yu
    Wu, Ming-Jiuan
    貢獻者: 藥學系
    生物科技系
    化粧品應用與管理系
    關鍵字: MACROPHAGE INFLAMMATORY PROTEIN-1
    HEME OXYGENASE-1
    NITRIC-OXIDE
    RAW264.7 MACROPHAGES
    MOUSE MACROPHAGES
    TNF-ALPHA
    KAPPA-B
    LIPOPOLYSACCHARIDE
    INHIBITION
    EXPRESSION
    日期: 2014
    上傳時間: 2015-05-06 21:18:39 (UTC+8)
    出版者: Hindawi Publishing Corporation
    摘要: The green fruit of Solanum integrifolium Poir. has been used traditionally as an anti-inflammatory and analgesic remedy in Taiwanese aboriginal medicine. The goal of this study is to evaluate the anti-inflammatory activity and mechanism of the green fruit extract of S. integrifolium. A bioactivity-guided fractionation procedure was developed to identify the active partition fraction. The methanol fraction (ME), with the highest phenolic content, exhibited the strongest inhibitory effect against LPS-mediated nitric oxide (NO) release and cytotoxicity in RAW264.7 macrophages. ME also significantly downregulated the expression of LPS-induced proinflammatory genes, such as iNOS, COX-2, IL-1 beta, IL-6, CCL2/MCP-1, and CCL3/MIP1 alpha. Moreover, ME significantly upregulated HO-1 expression and stimulated the activation of extracellular-signal-regulated kinase 1/2 (ERK1/2). Pretreatment of cells with the HO-1 inhibitor zinc protoporphyrin and MEK/ERK inhibitor U0126 attenuated ME's inhibitory activity against LPS-induced NO production. Taken together, this is the first study to demonstrate the anti-inflammatory activity of green fruit extract of S. integrifolium and its activity may be mediated by the upregulation of HO-1 expression and activation of ERK1/2 pathway.
    關聯: Biomed Research International, 953873
    顯示於類別:[化妝品應用與管理系(所)] 期刊論文
    [生物科技系(所)] 期刊論文
    [藥學系(所)] 期刊論文

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