Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/28504
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    Title: Anti-Inflammatory Effect and Mechanism of the Green Fruit Extract of Solanum integrifolium Poir.
    Authors: Wang, Lisu
    Chiou, Shu-Yuan
    Shen, Yi-Ting
    Yen, Fu-Tsun
    Ding, Hsiou-Yu
    Wu, Ming-Jiuan
    Contributors: 藥學系
    生物科技系
    化粧品應用與管理系
    Keywords: MACROPHAGE INFLAMMATORY PROTEIN-1
    HEME OXYGENASE-1
    NITRIC-OXIDE
    RAW264.7 MACROPHAGES
    MOUSE MACROPHAGES
    TNF-ALPHA
    KAPPA-B
    LIPOPOLYSACCHARIDE
    INHIBITION
    EXPRESSION
    Date: 2014
    Issue Date: 2015-05-06 21:18:39 (UTC+8)
    Publisher: Hindawi Publishing Corporation
    Abstract: The green fruit of Solanum integrifolium Poir. has been used traditionally as an anti-inflammatory and analgesic remedy in Taiwanese aboriginal medicine. The goal of this study is to evaluate the anti-inflammatory activity and mechanism of the green fruit extract of S. integrifolium. A bioactivity-guided fractionation procedure was developed to identify the active partition fraction. The methanol fraction (ME), with the highest phenolic content, exhibited the strongest inhibitory effect against LPS-mediated nitric oxide (NO) release and cytotoxicity in RAW264.7 macrophages. ME also significantly downregulated the expression of LPS-induced proinflammatory genes, such as iNOS, COX-2, IL-1 beta, IL-6, CCL2/MCP-1, and CCL3/MIP1 alpha. Moreover, ME significantly upregulated HO-1 expression and stimulated the activation of extracellular-signal-regulated kinase 1/2 (ERK1/2). Pretreatment of cells with the HO-1 inhibitor zinc protoporphyrin and MEK/ERK inhibitor U0126 attenuated ME's inhibitory activity against LPS-induced NO production. Taken together, this is the first study to demonstrate the anti-inflammatory activity of green fruit extract of S. integrifolium and its activity may be mediated by the upregulation of HO-1 expression and activation of ERK1/2 pathway.
    Relation: Biomed Research International, 953873
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles
    [Dept. of Biotechnology (including master's program)] Periodical Articles
    [Dept. of Pharmacy] Periodical Articles

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