A Novel Route for Preparation of Multifunctional Polymeric Nanocarriers for Stimuli-Triggered Drug Release

doi:10.1002/pola.27033

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/28491

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標題:	A Novel Route for Preparation of Multifunctional Polymeric Nanocarriers for Stimuli-Triggered Drug Release
作者:	Kuo, Chih-Yu Wang, Yu-Cheng Lee, Chia-Fen Chiu, Wen-Yen
貢獻者:	化粧品應用與管理系
關鍵字:	addition fragmentation chain-transfer (RAFT) controlled release nanoparticles poly(N-isopropylacrylamide) reversible self-assembly
日期:	2014-02
上傳時間:	2015-05-06 21:18:12 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	Fluorescence-incorporated, crosslinker-free, pH- and thermoresponsive nanocarriers were prepared by the incorporation of drug molecules into the thermoresponsive nanocapsules, which composed of poly(N-isopropylacrylamide) (PNIPAAm) with carboxylic acid end groups via temperature induced self-assembling method. Well-defined, pH-responsive carboxylic acid group-ended PNIPAAm homopolymer (HOOCPNIPAAmCOOH) was synthesized by reversible addition fragmentation chain transfer polymerization with S,S-bis(,-dimethyl--acetic acid)trithiocarbonate (CMP) as a chain transfer agent. Rhodamine 6G (R6G), the model drug, was used for three kinds of application: First, the nanostructure fixing; second, the fluorescence-labeling; and last, the controlled release modeling. The transmission electron microscope images showed the solution type dosing led to the encapsulation of drug molecules into the nanocarriers, while the powder-type drug-loading process significantly contributed to the structure preservation of nanocarriers. The controlled release behaviors with various pH values and temperatures were evaluated. These multifunctional nanocarriers have potential to be applied for the biomedical therapy by stimuli-responsive controlled release. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 561-571
關聯:	Journal of Polymer Science Part A-Polymer Chemistry, v.52 n.4, pp.561-571
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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