A Novel Route for Preparation of Multifunctional Polymeric Nanocarriers for Stimuli-Triggered Drug Release

doi:10.1002/pola.27033

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > Periodical Articles > Item 310902800/28491

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/28491

Title:	A Novel Route for Preparation of Multifunctional Polymeric Nanocarriers for Stimuli-Triggered Drug Release
Authors:	Kuo, Chih-Yu Wang, Yu-Cheng Lee, Chia-Fen Chiu, Wen-Yen
Contributors:	化粧品應用與管理系
Keywords:	addition fragmentation chain-transfer (RAFT) controlled release nanoparticles poly(N-isopropylacrylamide) reversible self-assembly
Date:	2014-02
Issue Date:	2015-05-06 21:18:12 (UTC+8)
Publisher:	Wiley-Blackwell
Abstract:	Fluorescence-incorporated, crosslinker-free, pH- and thermoresponsive nanocarriers were prepared by the incorporation of drug molecules into the thermoresponsive nanocapsules, which composed of poly(N-isopropylacrylamide) (PNIPAAm) with carboxylic acid end groups via temperature induced self-assembling method. Well-defined, pH-responsive carboxylic acid group-ended PNIPAAm homopolymer (HOOCPNIPAAmCOOH) was synthesized by reversible addition fragmentation chain transfer polymerization with S,S-bis(,-dimethyl--acetic acid)trithiocarbonate (CMP) as a chain transfer agent. Rhodamine 6G (R6G), the model drug, was used for three kinds of application: First, the nanostructure fixing; second, the fluorescence-labeling; and last, the controlled release modeling. The transmission electron microscope images showed the solution type dosing led to the encapsulation of drug molecules into the nanocarriers, while the powder-type drug-loading process significantly contributed to the structure preservation of nanocarriers. The controlled release behaviors with various pH values and temperatures were evaluated. These multifunctional nanocarriers have potential to be applied for the biomedical therapy by stimuli-responsive controlled release. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 561-571
Relation:	Journal of Polymer Science Part A-Polymer Chemistry, v.52 n.4, pp.561-571
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1568	View/Open

Loading...