| 標題: | N6-Substituted Adenosine Derivatives: Radioprotection, Whole Body Distribution, and Their Effects on Blood Preseure and Respiration Rates. |
| 作者: | Asakura H
Lee K
Ikegami S
Shikita M
Akaboshi S |
| 貢獻者: | 私立嘉南藥學專科學校
放醫研藥學研究部
東京大學醫學部放射醫學教室
國立清華大學核科學研究所 |
| 日期: | 1976 |
| 上傳時間: | 2014-12-25 15:03:39 (UTC+8) |
| 摘要: | Six derivatives of adenosine were examined on their pharmacological actions and whole body distribution in relation to their radioprotective action. They all caused a large drop in blood pressure and slowdown of pules rats. Respiration rate was slightly decreased with concomitant overbreathing. Labeled compounds of two of these adenosine derivatives, N-(14C-2-hydroxyethyl) adenosine and N(35S-2-mercaptoethyl) adenosine, were synthesized. Whole body autoradiographic study in mice showed a significant accumulation of the compounds in liver, spleen, intestinal mucosa and bone marrow. |
| 關聯: | 嘉南學報, n.2 pp.A16-A21 轉載 Journal of radiation research, v.15 n.1 pp.19-24 (1974) |
| 顯示於類別: | [嘉南學報] 2期 (1976)
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