N6-Substituted Adenosine Derivatives: Radioprotection, Whole Body Distribution, and Their Effects on Blood Preseure and Respiration Rates.

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Title:	N6-Substituted Adenosine Derivatives: Radioprotection, Whole Body Distribution, and Their Effects on Blood Preseure and Respiration Rates.
Authors:	Asakura H Lee K Ikegami S Shikita M Akaboshi S
Contributors:	私立嘉南藥學專科學校放醫研藥學研究部東京大學醫學部放射醫學教室國立清華大學核科學研究所
Date:	1976
Issue Date:	2014-12-25 15:03:39 (UTC+8)
Abstract:	Six derivatives of adenosine were examined on their pharmacological actions and whole body distribution in relation to their radioprotective action. They all caused a large drop in blood pressure and slowdown of pules rats. Respiration rate was slightly decreased with concomitant overbreathing. Labeled compounds of two of these adenosine derivatives, N-(14C-2-hydroxyethyl) adenosine and N(35S-2-mercaptoethyl) adenosine, were synthesized. Whole body autoradiographic study in mice showed a significant accumulation of the compounds in liver, spleen, intestinal mucosa and bone marrow.
Relation:	嘉南學報, n.2 pp.A16-A21 轉載 Journal of radiation research, v.15 n.1 pp.19-24 (1974)
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.2 (1976)

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